Machine Learning and Opioid Overdoses in Allegheny County

PI: Walid Gellad, MD, MPH
Funding Source: R.K. Mellon Foundation
July 2018 - June 2020, July 2020 - December 2025

This project, conducted in partnership with the Allegheny County Department of Human Services, develops and validates a machine learning algorithm that integrates Medicaid claims with human services and criminal justice data to predict individuals’ risk of opioid overdose within the 30 days from jail release. By leveraging a gradient boosting model with nearly 300 predictors—including social and justice-system factors—the study significantly improves prediction accuracy (C‑statistic = 0.92 vs. 0.87) and identifies high-risk subgroups to help target interventions effectively.

Read published results from this project

Integrating human services and criminal justice data with claims data to predict risk of opioid overdose among Medicaid beneficiaries: A machine-learning approach
Wei-Hsuan Lo-Ciganic, Julie M. Donohue, Eric G. Hulsey, Susan Barnes, Yuan Li, Courtney C. Kuza, Qingnan Yang, Jeanine Buchanich, James L. Huang, Christina Mair, Debbie L. Wilson, Walid F. Gellad
PLoS One, March 18, 2021

Overdose Risk Prediction Algorithms: The Need For A Comprehensive Legal Framework
Eric Hulsey, Tina B. Hershey, Lisa S. Parker, Courtney Kuza, Stephanie Fedro-Byrom, Walid F. Gellad
Health Affairs Forefront, November 22, 2022